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Test Code WEEP Western Equine Encephalitis Antibody, IgG and IgM, Serum

Useful For

Aiding the diagnosis of Western equine encephalitis

Method Name

Immunofluorescence Assay (IFA)

Reporting Name

West Equine Enceph Ab,IgG and IgM,S

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel                 

Acceptable: Red top                                        

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Clinical Information

The virus that causes western equine encephalitis (WEE) is widely distributed throughout the United States and Canada; disease occurs almost exclusively in the western states and Canadian provinces. The relative absence of the disease in the eastern United States probably reflects a paucity of the vector mosquito species, Culex tarsalis, and possibly a lower pathogenicity of local virus strains. The disease usually begins suddenly with malaise, fever, and headache, often with nausea and vomiting. Vertigo, photophobia, sore throat, respiratory symptoms, abdominal pain, and myalgia are also common. Over a few days, the headache intensifies; drowsiness and restlessness may merge into a coma in severe cases. In infants and children, the onset may be more abrupt than for adults. WEE should be suspected in any case of febrile central nervous system disease from an endemic area. Infants are highly susceptible to central nervous system disease and about 20% of cases are under 1 year of age. There is an excess of males with WEE clinical encephalitis, averaging about twice the number of infections detected in females. After recovery from acute disease, patients may require from several months to 2 years to overcome the fatigue, headache, and irritability. Infants and children are at higher risk of permanent brain damage after recovery than adults.

Reference Values

IgG: <1:10

IgM: <1:10

Reference values apply to all ages.

Day(s) and Time(s) Performed

May through October: Monday through Friday; 9 a.m.

 

November through April: Monday, Wednesday, Friday; 9 a.m.

Analytic Time

Same day/1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86654 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
WEEP West Equine Enceph Ab,IgG and IgM,S 69041-2

 

Result ID Test Result Name Result LOINC Value
8193 West Equine Enceph Ab, IgG, S 6957-5
87279 West Equine Enceph Ab, IgM, S 6958-3

NY State Approved

Yes