VGKC Ab with Reflex to LGI1 and CASPR2 Screen and Titer VGKCRFX

Synonyms
Allscripts (AEHR) Order Name	VGKC Ab with Reflex to LGI1 and CASPR2 Screen and Titer
Sunrise Clinical Manager (SCM) Order Name	LGKC Ab w/Reflex to LGI1 & CASPR2
Clinical Info	Screening test for voltage-gated potassium channel (VGKC) antibody receptor complex-associated autoantibodies with test reflex to CASPR2 and LGI1 antibodies. Antibodies are associated with acquired neuromyotonia, limbic encephalitis, painful neuropathy, Morvan syndrome, and rare tumors (eg, thymoma, small-cell lung cancer).
Specimen Type	Blood
Container	Gold Top Tube
Collection Instructions	Container/Tube: Gold To[ Tube Specimen: 4 mL serum ( 0.5 mL min) Transport Temperature: Refrigerated Separate serum from cells within 1 hour.
Transport Instructions	Refrigerated
Specimen Stability	3 Days Room Temperature Refrigerated : 2 weeks Frozen: 1 Month
Methodology	Quantitative Radioimmunoassay/Semi-Quantitative Indirect Fluorescent Antibody If VGKC is Indeterminate or Positive, LGI1 Antibody IgG and CASPR2 Antibody IgG will be added. If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
Days Performed	TAT 2 - 9 days Set up Tuesdays
Performing Laboratory	ARUP Laboratories
CPT	83519 LOINC Code: 41871-5
PDM	1759386
Result Interpretation Voltage-Gated Potassium Channel (VGKC) Antibody Negative 31 pmol or less Indeterminate 32 - 87 pmol/L Positive 88 pmol/L or greater Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer Less than 1:10 Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer Less than 1:10
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