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Test Code VDRLCSF VDRL, Cerebrospinal Fluid

Important Note

Sunrise Clinical Manager (SCM) Orderable:

VDRL Titer, CSF 

AllScripts (AEHR) Orderable: 

VDRL Titer, CSF

Performing Laboratory

LabCorp Burlington, NC

Methodology

Agglutination

Reference Values

NonReactive

Test Classification and CPT Coding

86592

 

LOINC Code: 22459-2

Specimen Requirements

Container/Tube:  Sterile tube

Specimen: 1 mL (0.2 mL min)

Transport Temperature: Refrigerated

Rejection: Hemolysis; gross bacterial contamination

Computer Interface Code

PDM #  5900700

Useful For

Test for syphilis, neurosyphilis

Information

A positive VDRL in a spinal fluid uncontaminated by serum is essentially diagnostic of neurosyphilis; however, a negative test may occur in 30% of patients with tabes dorsalis. The CSF VDRL may take years to become nonreactive after adequate therapy. In AIDS patients, serial CSF VDRL determinations may be needed when neurosyphilis is suspected. By requiring either a positive plasma RPR or FTA-ABS, seropositivity of CSF VDRL could increase to 90%.