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Test Code ULTRASCR Second Trimester Maternal Sequential Screen

Performing Laboratory

NTD  Eurofins

Reference Values

See Reference Report

Test Classification and CPT Coding





Day(s) and Time(s) Performed

Monday- Friday

Physician Office Specimen Requirements

Container/Tube: Gold top tube

Specimen:  2 ml serum ( 1 ml min)

Transport Temperature: Room Temperature

Collection Requirments:

   Pateints MUST have had the first trimester screen done though NTD

Test includes: AFP, free beta hCG, uE3 and inhibin-A

Performed pregnancy time frame: 15 weeks 0 days - 21 weeks 6 days

Computer Interface Code

PDM # 5900732

Used For

Part 2 of the Sequential Screen | Fß is performed in the second trimester of pregnancy, between 15 weeks and 21 weeks, 6 days gestation. This part of the test analyzes 4 biomarkers found in the mother's serum - alpha-fetoprotein (AFP), free beta hCG, unconjugated estriol, and inhibin-A. When the measurements from Part 2 are combined with those from Part 1, 95% of Down syndrome cases are detected at a 5.8% false positive rate and 95% of trisomy 18 and trisomy 13 cases are detected at a 0.3% false positive rate. Sequential Screen | Fß also screens for ONTDs, which can only be done in the second trimester. This test detects 90% of cases of open spina bifida and 98% of cases of anencephaly