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Test Code SHBG Sex Hormone-binding Globulin

Performing Laboratory

LabCorp Burlington, NC

Methodology

Electrochemiluminescence immunoassay (ECLIA)

Reference Values

• Male:

− 20-49 years: 16.5−55.9 nmol/L

− >49 years: 19.3−76.4 nmol/L

• Female:

− 20-49 years: 24.6−122.0 nmol/L

− >49 years: 17.3−125.0 nmol/L

 

TAT: 2 -3 Days

Test Classification and CPT Coding

84270

 

LOINC Code: 13967-5

Specimen Requirements

Container/Tube: Gold Top Tube or Red Top Tube

Specimen: 0.8 ml  Serum (0.3 mL min)

Transport Temperature: Refrigerated

Stability:  14 Days  Room Temperature, Refrigeratesd or Frozen

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Used For

Levels of SHBG are under the positive control of estrogens and thyroid hormones, and are suppressed by androgens. These influences dynamically control the liver synthesis of this carrier protein. Decreased levels of SHBG are frequently seen in hirsutism, virilization, obese postmenopausal women, and in women with diffuse hair loss. Increased levels may be present in cases of hyperthyroidism, testicular feminization, cirrhosis, male hypogonadism, pregnancy, women using oral contraceptives, and prepubertal children.

Limitations

As with all tests containing monoclonal mouse antibodies, erroneous findings may be obtained from samples taken from patients who have been treated with monoclonal mouse antibodies or who have received them for diagnostic purposes.1 In rare cases, interference due to extremely high titers of antibodies to streptavidin and ruthenium can occur.1 The test contains additives that minimize these effects.

Footnotes

1. SHBG on Elecsys 1010/2010 and Modular Analytics E170, 2007-09, V 7 [package insert]. Indianapolis, Ind: Roche Diagnostics; 2007.

Computer Interface Code

PDM# 5910520