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HelpTest Code SHBG Sex Hormone-binding Globulin
Performing Laboratory
LabCorp Burlington, NC
Methodology
Electrochemiluminescence immunoassay (ECLIA)
Reference Values
• Male:
− 20-49 years: 16.5−55.9 nmol/L
− >49 years: 19.3−76.4 nmol/L
• Female:
− 20-49 years: 24.6−122.0 nmol/L
− >49 years: 17.3−125.0 nmol/L
TAT: 2 -3 Days
Test Classification and CPT Coding
84270
LOINC Code: 13967-5
Specimen Requirements
Container/Tube: Gold Top Tube or Red Top Tube
Specimen: 0.8 ml Serum (0.3 mL min)
Transport Temperature: Refrigerated
Stability: 14 Days Room Temperature, Refrigeratesd or Frozen
Special Instructions
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Used For
Levels of SHBG are under the positive control of estrogens and thyroid hormones, and are suppressed by androgens. These influences dynamically control the liver synthesis of this carrier protein. Decreased levels of SHBG are frequently seen in hirsutism, virilization, obese postmenopausal women, and in women with diffuse hair loss. Increased levels may be present in cases of hyperthyroidism, testicular feminization, cirrhosis, male hypogonadism, pregnancy, women using oral contraceptives, and prepubertal children.
Limitations
As with all tests containing monoclonal mouse antibodies, erroneous findings may be obtained from samples taken from patients who have been treated with monoclonal mouse antibodies or who have received them for diagnostic purposes.1 In rare cases, interference due to extremely high titers of antibodies to streptavidin and ruthenium can occur.1 The test contains additives that minimize these effects.
Footnotes
1. SHBG on Elecsys 1010/2010 and Modular Analytics E170, 2007-09, V 7 [package insert]. Indianapolis, Ind: Roche Diagnostics; 2007.
Computer Interface Code
PDM# 5910520