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Test Code OMEGA-3 Omega-3 and -6 Fatty Acids

Performing Laboratory

Quest Diagnostics Nichols Institute San Juan Capistrano, CA


Chromatography/Mass Spectrometry


This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Values


Omega-3 (EPA+DHA) Index 1.4-4.9 %
Index <2.2: High
Index 2.2-3.2: Moderate
Index >3.2: Optimal
Omega-6/Omega-3 Ratio 5.7-21.3
EPA/Arachidonic Acid Ratio ≤0.2
Arachidonic Acid 5.2-12.9%
EPA 0.2-1.5 %
DHA 1.2-3.9 %


Test Classification and CPT Coding


Physician Office Specimen Requirements

Container/Tube: Lavender EDTA tube

Specimen: 2 mL EDTA Plasma (0.6 mL min)

Transport Temperature: Refrigerated Plasma



Used For

Clinical Significance

1. Baseline and monitoring of individuals with known CVD (acute and chronic) to determine Rx and compliance.
2. Identify patients with known CVD risk with low omega-3 levels who may be candidates for supplementation/therapy.
3. Monitor patients on omega-3 supplementation/therapy to determine efficacy of treatment.
4. Potential role in risk reduction for non-CVD outcomes-aged related macular degeneration, RA, cancer, etc. (early data).

Computer Interface Code

PDM #  1759536