LGI1 Ab IGG CBA-IFA with Refelx to Titer LGI1AB

Synonyms
Allscripts (AEHR) Order Name	LGI1 Ab IGG CBA-IFA with Refelx to Titer
Sunrise Clinical Manager (SCM) Order Name	LGI1 Ab IgG by CBA-IFA w/Rflx to Titer
Clinical Info	Aid in diagnosis of leucine-rich glioma inactivated 1 protein (LGI1) antibody disorders associated with limbic encephalitis, hyponatremia, and myoclonic movements. Disorders are rarely associated with tumors. Use to manage antibody-positive (LGI1) individual following immunotherapy and/or plasmapheresis Leucine-rich, glioma-inactivated 1 protein (LGI1) IgG antibody may occur as part of the voltage-gated potassium channel (VGKC) complex antibodies. The presence of LGI1 IgG antibody is mainly associated with limbic encephalitis, hyponatremia and myoclonic movements. LGI1 IgG antibody is rarely associated with tumors but may occur infrequently in Morvan syndrome, neuromyotonia and idiopathic epilepsy. The full-spectrum of clinical disorders associated with the LGI1 IgG antibody continues to be defined. Results should be interpreted in correlation with the patient's clinical history and other laboratory findings. This indirect fluorescent antibody assay utilizes leucine-rich, glioma-inactivated 1 protein (LGI1) transfected cell lines for the detection and semi-quantification of the LGI1 IgG antibody.
Specimen Type	Blood
Container	Gold Top Tube
Collection Instructions	Container/Tube: Gold top tube Specimen: 1 mL serum ( 0.2 mL min) Transport Temperature: Refrigerated Note: Separate serum from cells within 2 hours of collection
Transport Instructions	Refrigerated
Specimen Stability	2 Days Room Temperature 14 Days Refrigerated Year Frozen
Methodology	Semi-Quantitative Indirect Fluorescent Antibody
Days Performed	TAT: 2-9 Days
Performing Laboratory	ARUP Laboratories
CPT	86255 Reflex titer 86256 LOINC Code: 82978-8
PDM	1859768
Result Interpretation * Less than 1:10 If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply
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