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Test Code LDLD LDL Cholesterol, Direct, Plasma or Serum

Additional Codes

Sunrise Clinical Manager (SCM) Orderable:   LDL Cholesterol, Direct

AllScripts (AEHR) Orderable:  LDL Cholesterol, Direct

Performing Laboratory

Northwell Health Laboratories


Homogeneous Enzymatic Colorimetric

Reference Values

The table of LDL-C treatment objectives will be updated. It will include only two risk levels: one for general use, and a second one to be applied to persons with atherosclerotic cardiovascular disease (ASCVD) at very high risk1.


Patient’s Atherosclerotic

Cardiovascular Disease

(ASCVD)  Risk

Optimal Level (mg/dL)

LDL Cholesterol  (LDL-C)




All patients 

< 100

< 130

ASCVD at Very High Risk1

< 70

< 100


 -Non-HDL-Cholesterol (Non-HDL-C) is also a key target for cardiovascular risk reduction.  -Consider Familial Hypercholesterolemia when: LDL-C > 190 mg/dL or Non-HDL-C > 220   mg/dL.

       -LDL-C calculation using the Friedewald equation is not provided when triglycerides > 400         mg/dL, in which case we recommend repeating the test after fasting, if it was not done           before. 

      -When triglycerides >150 mg/dL, calculated LDL-C is provided but may still be inaccurate          (particularly when LDL-C < 70 mg/dL). It can be recalculated off-line using other equations              (e.g. Martin SS, Blaha MJ, Elshazly MB, et al. JAMA 2013;310:2061–8).

[1] Grundy, Scott M.,et al. "2019 AHA/ACC… guideline on the management of blood cholesterol: a report of the American College of                        Cardiology/American Heart Association Task Force on Clinical Practice Guidelines." Circulation;139:e1082–e114                 

         *These values apply only to persons 20 years and older.   



Test Classification and CPT Coding


Specimen Required

Submit only 1 of the following specimens:



Container/Tube:  Mint green-top (lithium heparin gel) tube(s)

Specimen:  1 mL of lithium heparin plasma

Transport Temperature:  Refrigerate

Collection Instructions:

Note:  1. Indicate plasma on request form.

2. Label specimen appropriately (plasma).



Container/Tube:  Gold-top tube(s)

Specimen:  1 mL of serum

Transport Temperature:  Refrigerate

Collection Instructions:

Note:  1. Indicate serum on request form.

2. Label specimen appropriately (serum).

Day(s) and Time(s) Performed

Monday through Sunday, Continuously

Computer Interface Code

PDM #  5300086