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Test Code JCVIRUS JC Virus DNA, Whole Blood, PCR

Performing Laboratory

LabCorp of America


Real-Time polymerase chain reaction (PCR)

Reference Values

None Detected

Test Classification and CPT Coding


Physician Office Specimen Requirements

Container/Tube: Lavender top (EDTA) tube

Specimen: 0.5 mL whole blood (0.2 mL minimum)

Transport Temperature: Refrigerated

Useful For

JCV is the etiologic agent of progressive multifocal leukoencephalopathy (PML) which is mainly seen in HIV patients, organ transplant patients, and other immunodeficient syndromes. In addition to PML, JCV also causes nephropathy in the renal transplant setting, although with considerably less frequency than BKV. JCV should always be considered in an immunocompromised patient with progressively deteriorating CNS function. Quantitative JCV DNA PCR can be used to detect JCV in CSF in the setting of CNS disease, and blood and urine in the setting of renal dysfunction. Quantitative DNA PCR can be used to track the course of infection as well as monitor response to treatment.

Computer Interface Code

PDM # 5908970