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Test Code JAK12 JAK2 Exons 12  Mutations, Qualitative, Leumeta®

Performing Laboratory

Quest Diagnostics Nicols Institute, Chantilly, VA

Methodology

Polymerase Chain Reaction-based DNA Sequencing

 

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Values

 Mutations: Not Detected

 

Test Classification and CPT Coding

81403

Specimen Required

Container/Tube: Lavender EDTA tube
Specimen: 5 ml Whole Blood from EDTA Lavender top tube(1 mL min)  or 1 mL min Bone Marrow(0.5 mL min))

Alternative Specimen(s)

5 mL whole blood or 1 mL bone marrow aspirate collected in: sodium heparin (green-top) tube • Fixed cell pellets • Extracted DNA from CLIA-certified laboratory

Transport Temperature: Refrigerated.

Stability: Room temperature: 7 days
                 Refrigerated: 7 days
                 Frozen: Unacceptable               

 

Note: Ship immediately to maintain sample stability. Stable for only 72 hours room temperature.

Day(s) and Time(s) Performed

Monday - Friday

Analytical time 3 days

Computer Interface Code

PDM #  5907501

Useful For

This DNA-based assay tests leukocytes from blood or bone marrow aspirate for mutations in exon 12 of JAK2, using an advanced DNA sequencing method. These mutations are associated with myeloproliferative neoplasms, particularly polycythemia vera