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Test Code IL28B IFNL3 (IL28B) Genotyping (rs12979860)

Performing Laboratory

LabCorp of America

Methodology

Real-time polymerase chain reaction (PCR) with allele-specific TaqMan® probes is used to detect a single nucleotide polymorphism (SNP) (rs12979860 C/T) on chromosome 19q13. The rs12979860 SNP maps 3 kilobases upstream of the IL28B gene (OMIM 607402), which encodes the type III interferon-λ3.

Reference Values

See Report

Test Classification and CPT Coding

81283

Specimen Required

Container/Tube: Lavender-top(EDTA) tube

Specimen: 7 mL whole blood (3mL min)

Transport Temperature: Room Temperature

Computer Interface Code

PDM #  5960145

Used For

This assay is used for genotyping IL-28B rs12979860

Limitations

IL28B genotype should be interpreted in the context of other clinical factors. This assay detects only a single base change in the IL28B gene (single nucleotide polymorphism rs12979860 C/T). No other polymorphisms are detected by this assay. Rare sequence polymorphisms close to rs12979860 may interfere with the genotype results of this assay.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.