Test Code IGEAB IgE Antibody (Anti-IgE IgG)
Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
Methodology
Immunoassay (IA)
Reference Values
<168 ng/mL
Specimen Requirements
Container/Tube: Red top tube (no gel)
Specimen: 0.5 mL serum (0.3 mL min) Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection)
Transport Temperature: Room Temperature
Stability: Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Patient Preparation Overnight fasting is preferred
Computer Interface Code
PDM # 20591434
CPT Coding
83520
LOINC Code: 51651-8
Used For
IgE Antibody (Anti-IgE IgG) - Chronic urticaria is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or to IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with chronic urticaria, and anti-IgE antibody has been identified in another 5% to 10%. The anti-IgE assay will quantify autoantibodies to IgE which will aid in the diagnosis and management of autoimmune chronic urticaria.