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Test Code IGEAB IgE Antibody (Anti-IgE IgG)

Performing Laboratory

Quest Diagnostics Nichols Inst San Juan Capistrano

Methodology

Immunoassay (IA)

Reference Values

<168 ng/mL

Specimen Requirements

Container/Tube: Red top tube (no gel)

Specimen: 0.5 mL serum (0.3 mL min) Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection)

Transport Temperature: Room Temperature

Stability: Room temperature: 7 days

                Refrigerated: 7 days

                Frozen: 28 days

 

 

Patient Preparation    Overnight fasting is preferred

 

Computer Interface Code

PDM # 20591434

CPT Coding

83520

 

LOINC Code: 51651-8

Used For

IgE Antibody (Anti-IgE IgG) - Chronic urticaria is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or to IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with chronic urticaria, and anti-IgE antibody has been identified in another 5% to 10%. The anti-IgE assay will quantify autoantibodies to IgE which will aid in the diagnosis and management of autoimmune chronic urticaria.