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Test Code HMGCR 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG


Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performing Laboratory

ARUP Laboratories

Specimen Required

Container/Tube: Gold top tube

Specimen: 0.5 mL serum ( 0.15 min)

Transport Temperature: Refrigerated

Stability:  2 Days Room Temperature

                 14 Days Refrigerated

                 1 Year Frozen

Reference Values

0-19 Units: Negative


IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatine kinase, perimysial pathology, and/or statin exposure.

Day(s) and Time(s) Performed


2 - 15 Days

Test Classification and CPT Coding



LOINC Code: 93493-5

Computer Interface Code

ODM # 1959739