Test Code HMGCR 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) Antibody, IgG
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performing Laboratory
ARUP Laboratories
Specimen Required
Container/Tube: Gold top tube
Specimen: 0.5 mL serum ( 0.15 min)
Transport Temperature: Refrigerated
Stability: 2 Days Room Temperature
14 Days Refrigerated
1 Year Frozen
Reference Values
0-19 Units: Negative
IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatine kinase, perimysial pathology, and/or statin exposure.
Day(s) and Time(s) Performed
Friday
2 - 15 Days
Test Classification and CPT Coding
83516
LOINC Code: 93493-5
Computer Interface Code
ODM # 1959739