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Test Code HLAB5701 HLA B57:01, Abacavir Hypersensitivity HLA Association Test

Performing Laboratory

LabCorp of Burlington

Methodology

Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSOP)

 

This is a class I allele-specific test.

Reference Values

See Report

 

TAT: 6 - 8 Days

Test Classification and CPT Coding

81381

Physician Office Specimen Requirements

Container/Tube: Lavender (EDTA) top tube

Specimen: 7.0 mL whole blood (3.0 mL min)

Transport Temperature: Room Temperature

Clinical Information

Abacavir hypersensitivity has been shown to be associated with the human leukocyte antigen (HLA) B*57:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response. The presence of the HLA-B*57:01 allele increases the susceptibility to abacavir hypersensitivity in several populations studied.

Computer Interface Code

PDM #  5902530