Growth Hormone Binding Protein GHBP

Synonyms

Allscripts (AEHR) Order Name

Growth Hormone Binding Protein

Sunrise Clinical Manager (SCM) Order Name

Growth Hormone Binding Protein

Clinical Info

Reduced or absent GHBP is found in GH insensitivity due to inactivating receptor binding mutations as typified by Laron dwarfism. The most clinically relevant use of GHBP measurements is to confirm suspected Laron dwarf GH insensitivity due to genetic GH receptor defect. Other forms of GH receptor insensitivity, however may have normal or high GHBP levels. The levels of GHBP may be explained by the underlying mechanism for insensitivity, accordingly, inability to dimerize, errors in the trans-membrane structure, or in downstream actions may have high or normal GHBP levels.
Studies show that GHBP levels decrease in acromegaly, with normalization on successful treatment. The converse is not true – high GHBP levels are not found associated with GH deficiency.
Limitations
Results of this test are labeled for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established by the manufacturer. The result should not be used for treatment or for diagnostic purposes without confirmation of the diagnosis by another medically established diagnostic product or procedure. The performance characteristics were determined by LabCorp.

Specimen Type

Blood

Container

Red Top Tube

Collection Instructions

Container/Tube: Red Top Tube
Specimen: 1 mL of serum ( 0.5 mL min)
Transport Temperature: Freeze
Collection
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection.

Transport Instructions

Freeze

Specimen Stability

7 Days Room Temperature
14 Days Refrigerated
14 Days Frozen

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Days Performed

Tuesday Morning Report available: 5 Days

Performing Laboratory

LabCorp

CPT

83520

PDM

5902450

Result Interpretation

 
3-8 Years 320-3820 pmol/L
9-13 Years 240-2890 pmol/L
14-17 Years 290-3140 pmol/L
Adult 400-4260 pmol/L
 

Forms

edit