Fluoxetine (Prozac) FLXTN

Synonyms
Allscripts (AEHR) Order Name	Fluoxetine (Prozac) Level, Serum
Sunrise Clinical Manager (SCM) Order Name	Fluoxetine (Prozac) Level, Serum
Clinical Info	Fluoxetine may be indicated as initial therapy in patients with concurrent obsessive-compulsive disorder.
Specimen Type	Blood
Container	Red Top Tube
Collection Instructions	Container/Tube: Plain, red-top tube(s) Specimen: 2 mL (minimum volume: 0.6 mL) of serum Transport Temperature: Refrigerate Stability: 14 Days Rom Temperautre, Refrigerated and Frozen Patient Preparation Collect at steady-state trough concentration. Specimen should be collected > 12 hrs after dose.
Transport Instructions	Refrigerate
Specimen Stability	14 Days Rom Temperautre, Refrigerated and Frozen Patient Preparation Collect at steady-state trough concentration. Specimen should be collected > 12 hrs after dose.
Methodology	Liquid chromatography/tandem mass spectrometry (LC/MS-MS) This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.. TAT: 4 - 7 Days
Days Performed
Performing Laboratory	LabCorp
CPT	80332 LOINC: 43117-1
PDM	5903870
Result Interpretation *Therapeutic*: fluoxetine: 91−302 ng/mL, norfluoxetine: 72−258 ng/mL. After dosing at 40 mg/day for 30 days, plasma concentration of fluoxetine in the range of 91−302 ng/mL and norfluoxetine in the range of 72−258 ng/mL were observed. In a well-designed pharmacokinetic study, with patients (N = 38) taking fluoxetine for five weeks of fixed doses between 20 mg and 80 mg per day, the majority of plasma concentrations were between 100−800 ng/mL for fluoxetine and between 100−600 ng/mL for norfluoxetine.
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