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Test Code ECHO Echovirus Antibody Panel, Serotypes 4,7,9,11,30

Performing Laboratory

Quest Nichols-Valencia


Complement Fixation (CF)

Reference Values

Reference range:  <1:8

<1:8  Antibody not detected
≥1:8  Antibody detected


<1:8  Antibody not detected
≥1:8  Antibody detected

Single titers ≥1:32 are indicative of recent infection. Titers of 1:8 and 1:16 may be indicative of either past or recent infection, since CF antibody levels persist for only a few months. A four-fold or greater increase in titer between acute and convalescent specimens confirms the diagnosis. There is considerable crossreactivity among enteroviruses; however, the highest titer is usually associated with the infecting serotype.


This test was developed and its performance characteristics have been determined by Quest Diagnostics Infectious Disease. Performance characteristics refer to the analytical performance of the test.

Test Classification and CPT Coding

86658 x 5

Physician Office Specimen Requirements

Container/Tube:  Plain, red-top tube(s) - Serum gel tube is acceptable.

Specimen:  2 mL (minimum volume:  1 mL) of serum

Transport Temperature:  Refrigerate

Day(s) and Time(s) Performed

Monday through Friday

Useful For

The current echovirus panel includes serotypes 4, 7, 9, 11, and 30. The echovirus serotypes used in this panel will vary depending upon current epidemiological data available from inhouse isolations CDC reports. Generally, the serotypes used are those most commonly associated with viral meningitis. Although there is cross-reactivity among the enteroviruses, most healthy people do not have detectable CF titers (>1:8). Therefore, detectable titers, especially those >1:32, should be considered diagnostic. Confirmed serodiagnosis is made by demonstration of a four-fold change in titers between acute and convalescent sera.

Computer Interface Code

PDM # 5915160