Cytochrome P450 2C19 Genotype CYP2C19GEN

Synonyms

Allscripts (AEHR) Order Name

Cytochrome p450 2C19 Genotype

Sunrise Clinical Manager (SCM) Order Name

Cytochrome P450 2C19 Genotype

Clinical Info

Cytochrome P450 2C19 (CYP2C19) is a drug-metabolizing enzyme involved in the metabolism of several clinically important drugs including the platelet aggregation inhibitor clopidogrel, the tricyclic antidepressants amitriptyline and nortriptyline, the selective serotonin reuptake inhibitors citalopram and sertraline, and some proton pump inhibitors including omeprazole and pantoprazole.

Specimen Type

Blood

Container

Lavender Top Tube

Collection Instructions

Container/Tube: Lavender top or Yellow ACD Tube
Specimen; 5 mL Whole Blood ( 3.0 mL min)
Transport Temperature: Room Temperature
Stability: 7 Days Room Temperature or Refrigerated
2 Years Frozen

Transport Instructions

Room Temperature

Specimen Stability

Room temperature Whole Blood: 28 days
Swabs: 2 Months
Refrigerated
Whole Blood: 28 days
Swabs: Unstable
Frozen
Whole Blood

Methodology

DNA analysis is performed by allele-specific real-time polymerase chain reactions (RT-PCR) to detect single-nucleotide polymorphisms (SNPs) within the CYP2C19 gene and to assign variant CYP2C19 *2, *3, *4, *5, *6, *7, *8, *9, *10, *17 and *35 alleles. *1 denotes detection of the reference (wild-type) sequence at the assessed alleles. No other variants in this gene are detected by this assay.

Days Performed

Performing Laboratory

Monogram Biosciences Inc
345 Oyster Point Blvd, S San Francisco, CA

CPT

81225
LOINC Code: 57132-3

PDM

5906087

Result Interpretation

See Report TAT: 8-11 Days

Forms

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