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Test Code COLLGN N-Telopeptides with Creatinine, Urine

Additional Codes

Sunrise Clinical Manager (SCM) Orderable:   N-Telepeptides w/Creatinine

AllScripts (AEHR) Orderable:  N-Telepeptides w/Creatinine (second void urine)

Performing Laboratory

Quest Nichols-Valencia


Calculation • Colorimetric

Reference Values


  18-29 years 12-99 nmol BCE/mmol creat
  30-59 years 9-60 nmol BCE/mmol creat
  Premenopausal 4-64 nmol BCE/mmol creat

Results are primarily used for monitoring the response to therapy. A value within the premenopausal reference range does not rule out osteoporosis nor the need for therapy.

Creatinine, Random, Urine

0-6 months 2-32 mg/dL
7-11 months   2-36 mg/dL
1-2 years 2-128 mg/dL
3-8 years 2-149 mg/dL
9-12 years 2-183 mg/dL
Male >12 years 20-370 mg/dL
Female >12 years 20-320 mg/dL


Test Classification and CPT Coding

82523 - collagen crosslinks

82570 - creatinine


Loinc: 14115-0

Physician Office Specimen Requirements

Container/Tube: Sterile leek-proof container

Specimen:   2 mL from a second-morning urine collection. Discard first-morning urine. No preservative.

Transport Temperature:  Refrigerated

Computer Interface Code

PDM #  5900486

Day(s) and Time(s) Performed

Tuesday,, Thursday and Saturday

TAT 2 - 5 Days

Useful For

NTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss. A decline of 30% or more of NTx over a six-month period suggests effective therapy.