CD33 CD33

Synonyms

Allscripts (AEHR) Order Name

Not Orderable

Sunrise Clinical Manager (SCM) Order Name

Not Orderable

Clinical Info

Classification of myeloid neoplasms and acute leukemias
CD33 is a transmembrane protein that is a member of the sialic acid-binding immunoglobulin-like lactic (Siglec) family. The exact function of CD33 is not known, but it may be involved in cell to cell adhesion. It is not expressed on hematopoietic stem cells but is expressed on maturing myelomonocytic cells. As granulocytes mature, there is progressive down regulation of CD33. Monocytes and macrophage/histiocytic cells maintain strong expression of CD33. In normal bone marrow, weak to moderate CD33 staining is seen on granulocytic and monocytic precursors, with strong staining in scattered mast cells. CD33 staining is useful for diagnosis of myeloid neoplasms and classification of acute leukemias. A therapeutic antibody targeting CD33 (gemtuzumab/Myelotarg) is available.

Specimen Type

Tissue, Bone Marrow, Body Fluid, CSF, Blood, Swab

Container

Green Top Tube

Collection Instructions

Specimen Type: TECHONLY
Supplies: Immunostain Technical Only Envelope (T693)
Specimen Type: Tissue
Container/Tube: Immunostain Technical Only Envelope
Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick
Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block
Specimen Minimum Volume:
Specimen Stability Information:
Specimen TypeTemperatureTimeSpecial Container
TECHONLYAmbient (preferred)
 Refrigerated 

Transport Instructions

Specimen Stability

Methodology

Immunohistochemistry

Days Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT

88342-TC, primary
88341-TC, if additional IHC

PDM

5200180

Result Interpretation

Forms

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