Test Code C1ESTIN C1 Esterase, Inhibitor Protein, Serum
Additional Codes
Sunrise Clinical Manager (SCM) Orderable:
C1 Esterase Inhibitor Total, Serum
AllScripts (AEHR) Orderable:
C1 Esterase Inhibitor Total, Serum
Performing Laboratory
Quest Diagnostics' Nichols Institute, Inc. - Chantilly
Methodology
Nephelometric
Specimen Requirements
Container/Tube: Gold-top tube(s)
Specimen: 1 mL of serum (0.5 mL min)
Transport Temperature: Refrigerated serum
Stability: 8 Days refrigerated
1 Year Frozen
Reference Values
21-39 mg/dL
Limitations
Fifteen percent of patient with the inherited form of the disease will test within range.
Test Classification and CPT Coding
86160
LOINC code: 4477-6
Day(s) and Time(s) Performed
Monday through Saturday
TAT: 2 Days
Useful For
The C1 esterase inhibitor protein is a normal constituent of serum which functions as a serine proteinase inhibitor of the serpin family. The C1 esterase inhibitor inhibits the complement proteases C1r and C1s, as well as the proteases kallikrein, factor XIa, XIIa and plasmin of the blood clotting system. The concentration of C1 esterase inhibitor protein is reduced to 10-30% of normal in patients with angioedema secondary to C1 esterase inhibitor deficiency (85% of patients with Hereditary Angioedema (HAE)); In 15% of patients with HAE, the concentrations of the inhibitor protein is normal but function is markedly reduced
Computer Interface Code
PDM # 5900345