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Test Code BARTG Bartonella Antibody Panel, IgG and IgM, Serum

Additional Codes

Mayo Test ID
BART

Reporting Name

Bartonella Ab Panel, IgG and IgM

Useful For

Diagnosis of Bartonella infection, especially in the context of a cat scratch

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 30 days
  Frozen  30 days

Reference Values

Bartonella henselae

IgG: <1:128

IgM: <1:20

 

Bartonella quintana

IgG: <1:128

IgM: <1:20

Day(s) and Time(s) Performed

Monday through Saturday; 9 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86611 x 4

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BART Bartonella Ab Panel, IgG and IgM In Process

 

Result ID Test Result Name Result LOINC Value
15659 Bart Henselae IgG 6954-2
15660 Bart Henselae IgM 6955-9
15661 Bart Quintana IgG 44827-4
15662 Bart Quintana IgM 44825-8

Clinical Information

Bartonella henselae and Bartonella quintana are small, rod-shaped, pleomorphic, gram-negative bacteria. The human body louse (Pediculus humanis) is the proposed vector for B quintana. No animal reservoir has been determined for B quintana. The domestic cat is believed to be both a reservoir and vector for B henselae. Cats may infect humans directly through scratches, bites, or licks, or indirectly through an arthropod vector. Humans remain the only host in which Bartonella infection leads to significant disease.

 

The sight of entry for Bartonella is through openings in the skin. Microscopically, Bartonella lesions appear as rounded aggregates that proliferate rapidly. These aggregates are masses of Bartonella bacteria. Warthin-Starry-staining has shown that Bartonella organisms can be present within the vacuoles of endothelial cells, in macrophages, and between cells in areas of necrosis. Occasionally organisms are seen in the lumens of vessels. While cutaneous lesions are common, disseminated tissue infection by Bartonella has been seen in the blood, lymph nodes, spleen, liver, bone marrow, and heart. B henselae has been associated with cat scratch disease (CSD), peliosis hepatitis (PH), bacillary angiomatosis (BA), and endocarditis. B quintana has been associated with trench fever, BA, and endocarditis. BA is a vascular proliferative disease usually involving the skin and regional lymph nodes.

 

CSD begins as a cutaneous papule or pustule that usually develops within a week after an animal contact. Regional lymphadenopathy, which follows, is the predominant clinical feature of CSD. Trench fever, which was a significant problem during World War I and World War II, is characterized by a relapsing fever and severe pain in the shins. PH and febrile bacteremia syndrome are both syndromes that have afflicted patients with AIDS or those patients who are immunocompromised. While trench fever and CSD are usually self-limiting illnesses, the other Bartonella-associated diseases can be life-threatening.

 

Interest in B quintana and B henselae has recently increased since its increased prevalence in patients with AIDS, in transplant patients, and those with suppressed immunity.

Analytic Time

Same day/1 day

Testing Algorithm

Includes Bartonella henselae and Bartonella quintana.

 

See Infective Endocarditis: Diagnostic Testing for Identification of Microbiological Etiology in Special Instructions.

NY State Approved

Yes

Method Name

Immunofluorescence Assay (IFA)

Northwell Health Laboratories Additional Information:

Computer Interface Code

   PDM # 5908770