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Test Code ADRENALAB 21-Hydroxylase Antibodies, Serum

Additional Codes

Mayo Test ID

Reporting Name

21-Hydroxylase Ab, S
Northwell Health Laboratories Note:

Adrenal Antibodies

Useful For

Investigation of adrenal insufficiency


Aid in the detection of those at risk of developing autoimmune adrenal failure in the future

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Specimen Required

Collection Container/Tube: 

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Specimen Minimum Volume

0.19 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 14 days
  Refrigerated  7 days

Reference Values

<1 U/mL

Reference values apply to all ages.

Day(s) and Time(s) Performed

Thursday; 2 p.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
OH21 21-Hydroxylase Ab, S In Process


Result ID Test Result Name Result LOINC Value
81970 21-Hydroxylase Ab, S 17781-6

Clinical Information

Chronic primary adrenal insufficiency (Addison disease) is most commonly caused by the insidious autoimmune destruction of the adrenal cortex and is characterized by the presence of adrenal cortex autoantibodies in the serum. It can occur sporadically or in combination with other autoimmune endocrine diseases, that together comprise Type I or Type II autoimmune polyglandular syndrome (APS).


The microsomal autoantigen 21-hydroxylase (55 kilodalton) has been shown to be the primary autoantigen associated with autoimmune Addison disease. 21-Hydroxylase antibodies are markers of autoimmune Addison disease, whether it presents alone, or as part of Type I or Type II (APS).

Analytic Time

2 days

Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK; Gross OK



NY State Approved


Method Name

Immunoabsorption Assay

Northwell Health Laboratories Additional Information:

Computer Interface Code

    PDM #  5902020