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Test Code ADAMTS13 ADAMTS13 Activity Reflex Profile

Additional Codes

Sunrise Clinical Manager (SCM) Orderable:   Adamts 13 Assay

AllScripts (AEHR) Orderable:  Adamts13 Evaluation

 

Performing Laboratory

LabCorp, Burlington, NC

Methodology

Liquid chromatography‐tandem mass spectrometry (LC/MS-MS)

 

Reference Values

See Report

 

Note:  ADAMTS13 activity reflex to ADAMTS13 antibody when activity is less than 30%

 

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration.

Test Classification and CPT Coding

85397

 

83520 (if antibody performed)

 

LOINC Code:  53622-7  Activity

                        40824-5  Antibody

Specimen Required

Container/Tube: Blue top(sodium citrate) tube

Specimen: 1.0  mL citrated plasma ( 0.3 mL min-does not alow for repeat testing)

Transport Temperature: Freeze plasma

 

Collection: Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples. When noncitrate tubes are collected for other tests, collect sterile and no additive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tubes. Serum gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and (using a transfer pipette) carefully remove two-thirds of the plasma without disturbing the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a aliquot tube and freeze.

 

Computer Interface Code

PDM #  5910042

Used for

Differentiating thrombotic thrombocytopenic purpura (TTP) from a number of clinically similar conditions. Reflex to antibody assay is used to differentiate congenital from autoimmune ADAMTS13 deficiency.