Test Code ACBNAB Acetylcholine Binding Antibody, Serum
Performing Laboratory
Quest Nichols-Valencia
Methodology
Radioimmunoassay (RIA)
Reference Values
Negative | ≤0.30 nmol/L | |
Equivocal | 0.31-0.49 nmol/L | |
Positive | ≥0.50 nmol/L |
Test Classification and CPT Coding
83519
LOINC: 11034-6
Physician Office Specimen Requirements
Container/Tube: Gold-top tube(s)
Specimen: 1 mL of serum(0.5 mL min)
Transport Temperature: Refrigerate
Stability: 14 days Refrigerated
30 Days Frozen
Day(s) and Time(s) Performed
Sat up Tuesday - Saturday
TAT: 2 - 3 days
Computer Interface Code
PDM # 5901700
Useful For
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.