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Test Code 5HIAARU 5-HIAA (Serotonin), Random Urine

Additional Codes

Sunrise Clinical Manager (SCM) Orderable:  5 HIAA Random Urine

AllScripts (AEHR) Orderable: 5 HIAA Random Urine

Performing Laboratory

Quest Diagnostics Nichols Institute, Chantilly VA


High Performance Liquid Chromatography (HPLC)

Specimen Required

Container/Tube: Sterile Urine Container

Specimen:   10 mL random urine (5mL min) 

      After urine collection, add 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6

Transport Temperature: Refrigerated

Stability: Room temperature: 7 days
                Refrigerated: 30 days
                Frozen: 30 days

TAT: 3 - 4 Days

Patient Preparation:

Patient should avoid food high in indoles: avocados, banana, tomato, plum, walnut, pineapple, and eggplant. Patient should also avoid tobacco, tea and coffee three days prior to specimen collection.



Reference Values


5-HIAA , Random Urine


2-10 Years ≤12.0  mg/g creat 
 >10 Years ≤10.0  mg/g creat


Creatinine, Random Urine

≤6 Months 2-32 mg/dL
7-11 Months   2-36 mg/dL
1-2 Years 2-128 mg/dL
3-8 Years 2-149 mg/dL
9-12 Years 2-183 mg/dL
>12 Years Male 20-370 mg/dL
>12 Years Female 20-320 mg/dL


Test Classification and CPT Coding


Computer Interface Code

PDM # 5908000

Useful For

Values above 10 mg/24 hours occur in carcinoid syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration. Drugs which can interfere with testing due to physiologic response: Acetaminophen, alpha and beta blockers, atenolol, bromocriptine, broncholdilators, clonidine, digoxin, isoniazid, L-dopa, labetelol, methyldopa, monoamine oxidase inhibitors, nitroglycerin, sympathomimetic amines, phenobarbital, phenothiazines, phentolamine, reserprine, salicylates, tricyclic antidepressants.