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Test Code 14-3 3 Protein TAU, CSF 14-3-3 Protein Tau, CSF

Performing Laboratory

National  Prion Disease Pathology Surveillance Center (NPDPSC)


Immunoassay • RT-QulC (real-time quaking-induced conversion)

Reference Values

RT-QulC                      Negative

T-Tau protein (CSF)      0 - 1149 pg/mL

14-3 3 protein (CSF)   Negative


TAT: 21 Days

CPT Coding





LOINC code: 19146-0

Specimen Requirements

Collection Container/Tube: Sterile vial

 Container/Tube: Plastic vial

Specimen Volume: 2-5 mL CSF(min 2 mL)

Stability   Room temperature: 24 hours

                  Refrigerated: 14 days

                  Frozen: Indefinitely


Collection Instructions:

1. Obtain aliquot from second collection vial.

2. Hemolyzed specimens will give false-positive results. Specimens should be centrifuged to remove any red cells before shipping. The test will be canceled if there is any level of hemolysis present.

Transport Temperature:  Frozen CSF

Additional Information:

1. Specimens that have not been kept refrigerated or that have been tested for other analytes previously may give a false-positive result.

2. Separate specimens should be submitted when multiple tests are ordered. This will reduce the risk of test cancellation due to stability problems.

Please send sample with requsuiton found in Resources.

Computer Interface Code

PDM # 1759541

Used For

Supporting, in conjunction with other tests, a diagnosis of Creutzfeldt-Jakob disease in patients with rapidly progressive dementia when other neurodegenerative conditions have been excluded