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Test Code VMARU Vanillylmandelic Acid (VMA), Random, Urine

Reporting Name

Vanillylmandelic Acid, Random, U

Useful For

Screening children for catecholamine-secreting tumors with a random urine collection when requesting vanillylmandelic acid only


Supporting a diagnosis of neuroblastoma


Monitoring patients with a treated neuroblastoma

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Container/Tube: Plastic, 10-mL urine tube (T068)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Adjust the random urine pH to a level between 1 and 5 by adding 50% acetic acid dropwise and checking the pH.

Additional Information:

1. Patient's age is required.

2. Administration of L-dopa may falsely increase vanillylmandelic acid results; it should be discontinued 24 hours prior to and during collection of specimen.

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Frozen  180 days

Reference Values

<1 year: <25.0 mg/g creatinine

1 year: <22.5 mg/g creatinine

2-4 years: <16.0 mg/g creatinine

5-9 years: <12.0 mg/g creatinine

10-14 years: <8.0 mg/g creatinine

≥15 years (adults): <7.0 mg/g creatinine

Day(s) and Time(s) Performed

Monday through Friday; 8 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
VMAR Vanillylmandelic Acid, Random, U 3124-5


Result ID Test Result Name Result LOINC Value
60274 Vanillylmandelic Acid, Random, U 3124-5

Clinical Information

Vanillylmandelic acid (VMA) and other catecholamine metabolites (homovanillic acid [HVA] and dopamine) are typically elevated in patients with catecholamine-secreting tumors (eg, neuroblastoma, pheochromocytoma, and other neural crest tumors). VMA and HVA levels may also be useful in monitoring patients who have been treated as a result of one of the above-mentioned tumors.

Analytic Time

2 days (not reported on Sundays)

NY State Approved


Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Northwell Health Laboratories Additional Information:

Computer Interface Code

   PDM # 5901370