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Test Code ULTRASCR Second Trimester Maternal Sequential Screen

Performing Laboratory

NTD  Eurofins

Reference Values

See Reference Report

Test Classification and CPT Coding

84704

82677

82105

86336

Day(s) and Time(s) Performed

Monday- Friday

Physician Office Specimen Requirements

Container/Tube: Gold top tube

Specimen:  2 ml serum ( 1 ml min)

Transport Temperature: Room Temperature

Collection Requirments:

   Pateints MUST have had the first trimester screen done though NTD

Test includes: AFP, free beta hCG, uE3 and inhibin-A

Performed pregnancy time frame: 15 weeks 0 days - 21 weeks 6 days

Computer Interface Code

PDM # 5900732

Used For

Part 2 of the Sequential Screen | Fß is performed in the second trimester of pregnancy, between 15 weeks and 21 weeks, 6 days gestation. This part of the test analyzes 4 biomarkers found in the mother's serum - alpha-fetoprotein (AFP), free beta hCG, unconjugated estriol, and inhibin-A. When the measurements from Part 2 are combined with those from Part 1, 95% of Down syndrome cases are detected at a 5.8% false positive rate and 95% of trisomy 18 and trisomy 13 cases are detected at a 0.3% false positive rate. Sequential Screen | Fß also screens for ONTDs, which can only be done in the second trimester. This test detects 90% of cases of open spina bifida and 98% of cases of anencephaly