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Test Code TCL1A T-Cell Leukemia/Lymphoma Protein 1A (TCL1A) Immunostain, Technical Component Only


Advisory Information


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope (T693)

Preferred: 2 unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Additional Information:

1. Information on accessing digital images of IHC stains and the manual requisition form can be accessed through this website: www.mayomedicallaboratories.com/test-info/ihc/index.html

2. Clients ordering stains using a manual requisition form will not have access to digital images.

3. Clients wishing to access digital images must place the order for IHC stains electronically. Information regarding digital imaging can be accessed through this website: www.mayomedicallaboratories.com/test-info/ihc/faq.html


Useful For

Identification of T-cell leukemia and lymphoma protein overexpression in neoplasms

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IHTOI IHC Initial, Tech Only No No
IHTOA IHC Additional, Tech Only No No

Method Name

Immunohistochemistry

Reporting Name

TCL1A IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

T-cell leukemia/lymphoma (TCL) proteins augment AKT signal transduction and enhance cell proliferation and survival. Inversion or translocations involving the TCL-1 gene are present in more than 90% of T-cell prolymphocytic leukemias, resulting in overexpression of the TCL-1 protein. TCL-1 is also found in plasmacytoid monocytes in reactive tissues, and the putative malignant counterpart, blastic plasmacytoid dendritic cell neoplasm. In normal tonsil, expression is limited to the B-cell compartment.

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TCL1A TCL1A IHC, Tech Only In Process

 

Result ID Test Result Name Result LOINC Value
70873 TCL1A IHC, Tech Only No LOINC Needed

NY State Approved

Yes