Sign in →

Test Code QFEVER Q Fever Antibody, IgG and IgM, Serum

Reporting Name

Q Fever Ab, IgG and IgM, S
Northwell Health Laboratories Note:

Coxiella burnetii Abs

Useful For

Diagnosing Q fever

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

Q FEVER PHASE I ANTIBODY, IgG

<1:16

 

Q FEVER PHASE II ANTIBODY, IgG

<1:16

 

Q FEVER PHASE I ANTIBODY, IgM

<1:16

 

Q FEVER PHASE II ANTIBODY, IgM

<1:16

Day(s) and Time(s) Performed

Monday through Friday; 9 a.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86638 x 4

LOINC Code Information

Test ID Test Order Name Order LOINC Value
QFP Q Fever Ab, IgG and IgM, S 77175-8

 

Result ID Test Result Name Result LOINC Value
80965 Q Fever Phase I Ab, IgG 34716-1
24011 Q Fever Phase II Ab, IgG 34717-9
81115 Q Fever Phase I Ab, IgM 9710-5
24009 Q Fever Phase II Ab, IgM 9711-3
24010 Interpretation 69048-7

Clinical Information

Q fever, a rickettsial infection caused by Coxiella burnetii, has been recognized as a widely distributed zoonosis with the potential for causing both sporadic and epidemic disease. The resistance of Coxiella burnetii to heat, chemical agents, and desiccation allows the agent to survive for extended periods outside the host.

 

The infection is spread by the inhalation of infected material, mainly from sheep and goats. They shed the organism in feces, milk, nasal discharge, placental tissue, and amniotic fluid.

 

The clinical spectrum of disease ranges from unapparent to fatal. Respiratory manifestations usually predominate; endocarditis and hepatitis can be complications.

 

During the course of the infection, the outer membrane of the organism undergoes changes in its lipopolysaccharide structure, called phase variation. Differences in phase I and phase II antigen presentation can help determine if the infection is acute or chronic:

-In acute Q fever, the phase II antibody is usually higher than the phase I titer, often by 4-fold, even in early specimens. Although a rise in phase I as well as phase II titers may occur in later specimens, the phase II titer remains higher.

-In chronic Q fever, the reverse situation is generally seen. Serum specimens drawn late in the illness from chronic Q fever patients demonstrate significantly higher phase I titers, sometimes much greater than 4-fold.

-In the case of chronic granulomatous hepatitis, IgG and IgM titers to phase I and phase II antigens are quite elevated, with phase II titers generally equal to or greater than phase I titers.

-Titers seen in Q fever endocarditis are similar in magnitude, although the phase I titers are quite often higher than the phase II titers.

Analytic Time

Same day/1 day

NY State Approved

Yes

Method Name

Indirect Immunofluorescence

Testing Algorithm

See Infective Endocarditis: Diagnostic Testing for Identification of Microbiological Etiology in Special Instructions.

Northwell Health Laboratories Additional Information:

Computer Interface Code

   PDM # 5902682