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Test Code PGL/PCC Paraganglioma/Pheochromocytoma Panel

Performing Laboratory

BioReference- GeneDx

Methodology

Exon Array CGH, Next-gen Sequencing

Reference Values

See Report

 

Includes Genes: FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

Physician Office Specimen Requirements

Container/Tube:  Lavender top tube

Specimen: 2 - 5 mL whole blood

Transport Temperature: Room Temperature

 

Computer Interface Code

PDM #  1659877

Useful For

  • 1) The family history is suggestive of a predisposition to PGL/PCC. Although SDHB, SDHC, and SDHD are the genes that are the most often associated with classic forms of hereditary paraganglioma/pheochromocytoma syndrome, there are several other genes that cause an increased risk of these tumors. The OncoGeneDx PGL/PCC Panel includes analysis of these genes as well as nine other genes affecting PCC/PGL risk. Thus, the OncoGeneDx PGL/PCC Panel offers increased clinical sensitivity compared to testing only for the most commonly associated genes. Furthermore, panel testing is more cost effective than stepwise genetic testing (for example, ordering SDHB testing followed by additional genetic testing, if negative).
  • 2) The differential diagnosis includes various hereditary syndromes. For example, if the family history consists of multiple types of tumors or cancers, such as paraganglioma in addition to renal cancer, this may be associated with a syndrome such as VHL or hereditary PGL/PCC syndrome.
  • 3) Genetic testing has already been ordered due to a family history suggestive of a hereditary tumor predisposition and all results have been negative. OncoGeneDx PGL/PCC Panel includes genes whose role in cancer/tumor predisposition has been described recently in addition to genes associated with classic hereditary tumor syndromes.

CPT Coding

81405

81406

81407x2