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Test Code NEURNTN Gabapentin, Serum

Additional Codes

Mayo Test ID

Reporting Name

Gabapentin, S

Useful For

Monitoring serum gabapentin concentrations   Assessing compliance   Adjusting dosage in patients

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum Red

Specimen Required

Container/Tube: Red top

Specimen Volume: 1 mL

Collection Instructions:

1. Draw specimen immediately before next scheduled dose.

2. Spin down within 2 hours of draw.

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

2.0-20.0 mcg/mL


Toxic Range: ≥25.0 mcg/mL

Day(s) and Time(s) Performed

Tuesday through Saturday; 12 a.m.,

Saturday; 4 p.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
GABA Gabapentin, S In Process


Result ID Test Result Name Result LOINC Value
80826 Gabapentin, S 9738-6

Clinical Information

Gabapentin is an antiepileptic drug that is effective in treating seizures, neuropathies, and a variety of neurological and psychological maladies. Although designed as a gamma amino butyric acid (GABA) analogue, gabapentin does not bind to GABA receptors, nor does it affect the neuronal uptake or degradation of GABA. In fact, the precise mechanism by which it exerts its analgesic and anticonvulsant effects is unknown.


After oral administration and absorption, gabapentin circulates essentially unbound to serum proteins. In addition, gabapentin does not undergo hepatic metabolism unlike most other antiepileptic drugs and is eliminated almost entirely by renal excretion with a clearance that approximates the glomerular filtration rate. The elimination half-life is 5 to 7 hours in patients with normal renal function.


Since gabapentin does not bind to serum proteins, it does not exhibit pharmacokinetic variability and interactions with other highly protein-bound medications (ie, phenytoin). In addition, the lack of hepatic metabolism eliminates the interactions with other hepatically cleared medications which can induce/inhibit hepatic drug metabolizing enzyme systems (cytochrome P450s). Therefore, gabapentin serum concentrations are not changed following the addition or discontinuation of other common anticonvulsants (ie, phenobarbital, phenytoin, carbamazepine, or valproic acid), nor are their serum concentration altered upon the addition or discontinuation of gabapentin.


In general, adverse effects with gabapentin are infrequent and usually resolve with continued treatment. The most common side effects include somnolence, dizziness, ataxia, and fatigue. Experience to date indicated that gabapentin is safe and relatively nontoxic.

Analytic Time

Same day/1 day

NY State Approved


Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)


If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen (

Northwell Health Laboratories Additional Information:

Computer Interface Code

   PDM # 5901000