Sign in →

Test Code JCVCSF JC Virus, Molecular Detection, PCR, Spinal Fluid

Additional Codes

Mayo Test ID
LCJC

Reporting Name

JC Virus PCR, CSF

Useful For

Aids in diagnosing progressive multifocal leukoencephalopathy due to JC virus (JCV)

 

This test is not to be used as a diagnostic tool for Creutzfeldt-Jakob disease (CJD).

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

CSF


Specimen Required


Supplies: Aliquot Tube, 5 mL (T465)

Preferred: 12 x 75-mm screw cap vial (T465)

Acceptable: Sterile screw cap vial

Container/Tube: Sterile vial

Specimen Volume: 0.5 mL

Collection Instructions: Do not centrifuge.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

Negative

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

87798

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LCJC JC Virus PCR, CSF In Process

 

Result ID Test Result Name Result LOINC Value
88909 JC Virus PCR, CSF 33295-7

Clinical Information

JC virus (JCV), a member of the genus Polyomavirus, is a small nonenveloped DNA-containing virus. Primary infection occurs in early childhood, with a prevalence of greater than 80%.(1) The virus is latent but can reactivate in immunosuppressed patients, especially those with AIDS.

 

JCV is recognized as the etiologic agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system.(2,3) Histologic examination of brain biopsy tissue may reveal characteristic pathologic changes localized mainly in oligodendrocytes and astrocytes. Detection of JCV DNA by PCR (target gene, large T antigen) in the cerebrospinal fluid specimens of patients with suspected PML infection has replaced the need for biopsy tissue for laboratory diagnosis.(4) Importantly, the PCR test is specific with no cross-reaction with BK virus, a closely related polyomavirus.

Analytic Time

Monday through Thursday: 2 days; Friday, Saturday: 3 days

NY State Approved

Yes

Method Name

Real-Time Polymerase Chain Reaction (PCR)/DNA Probe Hybridization

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request Form (T244) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/microbiology_test_request_form.pdf)

Northwell Health Laboratories Additional Information:

Computer Interface Code

    PDM #  5905860