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Test Code C1ESTIN C1 Esterase, Inhibitor, Serum

Performing Laboratory

Quest Diagnostics' Nichols Institute, Inc. - Chantilly

Methodology

Nephelometric

Reference Values

21-39 mg/dL

Test Classification and CPT Coding

83883

Day(s) and Time(s) Performed

Monday through Saturday

Physician Office Specimen Requirements

Container/Tube:  Gold-top tube(s)

Specimen:  1 mL of serum

Transport Temperature:  Refrigerate

Useful For

The C1 esterase inhibitor protein is a normal constituent of serum which functions as a serine proteinase inhibitor of the serpin family. The C1 esterase inhibitor inhibits the complement proteases C1r and C1s, as well as the proteases kallikrein, factor XIa, XIIa and plasmin of the blood clotting system. The concentration of C1 esterase inhibitor protein is reduced to 10-30% of normal in patients with angioedema secondary to C1 esterase inhibitor deficiency (85% of patients with Hereditary Angioedema (HAE)); In 15% of patients with HAE, the concentrations of the inhibitor protein is normal but function is markedly reduced

Computer Interface Code

pdm# 5900345