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Test Code ASCA Saccharomyces cerevisiae IgA and IgG Antibodies, Serum

Performing Laboratory

Northwell Health Laboratories

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Reference Values

ASCA IgA or ACSA IgG

Negative:  ≤20.0 Units

Equivocal:  20.1-24.9 Units

Weak positive:  25.0-34.9 Units

Positive:  ≥35.0 Units

Test Classification and CPT Coding

83520 x 2

Day(s) and Time(s) Performed

Two times per week

Physician Office Specimen Requirements

Container/Tube:  Gold-top tube(s)

Specimen:  1 mL of serum

Transport Temperature:  Refrigerate

Computer Interface Code

PDM #  5702020

Useful For

Antibodies to Saccharomyces cerevisiae are found in approximately 75% of patients with Crohn's disease, 15% of patients with ulcerative colitis, and 5% of the healthy population. High titers of antibody increase the likelihood of disease, and specifically Crohn's disease, and are associated with more aggressive disease.