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Test Code ACYL Acylcarnitines, Quantitative, Plasma

Performing Laboratory

Mt. Sinai

Methodology

Liquid Chromatography/Mass Spectrometry

Reference Values

See report.

Includes:

C2             

C3             

C4             

C5:1           

C5             

C4-OH          

C6             

C5-OH          

C8:1           

C8             

C3-DC          

C10:2          

C10:1          

C10            

C4-DC          

C5-DC/C10-OH   

C12:1          

C12            

C6-DC          

C12:1-OH       

C12-OH         

C14:2          

C14:1          

C14            

C14:1-OH       

C14-OH         

C16:1          

C16            

C16:1-OH       

C16-OH         

C18:2          

C18:1          

C18            

C18:2-OH       

C18:1-OH       

C18-OH

Test Classification and CPT Coding

80500

82017

82492

Day(s) and Time(s) Performed

Monday through Friday

Specimen Required

 Container/Tube: Green-top (sodium heparin)
Specimen: 1-2 mL plasma (minimum volume: 0.5 mL)

Transport Temperature: Frozen

 

Note: Centrifuge immediately after collection and pour off plasma in transport vial. Freeze immediately.

Useful For

Acylcarnitines are intermediate metabolites involved with fatty acid oxidation and detoxification of acylCoAs from organic acid metabolism. The test is valuable in diagnosing and monitoring patients with a clinical suspicion or positive newborn screen for fatty acid oxidation disorders and some organic acidemias. The acylcarnitine profile is obtained by liquid chromatography and tandem mass spectrometry which provides quantitative evaluations of individual acylcarnitine species as well as the metabolic profile in plasma and dried blood spot samples. For more accurate diagnosis, it is recommended that acylcarnitine analysis should be performed in conjunction with plasma amino acid analysis and urinary organic acid analysis for initial evaluation of patients.

Computer Interface Code

PDM # 5910515