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Test Code ACETAMIN Acetaminophen, Serum

Performing Laboratory

Northwell Health Laboratories - Manhasset

Methodology

Immunoassay

Reference Values

10-30 µg/mL

Test Classification and CPT Coding

80307

Physician Office Specimen Requirements

Container/Tube:  Plain, red-top tube(s) - Serum gel tube is not acceptable.

Specimen:  1 mL of serum

Transport Temperature:  Refrigerate

Day(s) and Time(s) Performed

Monday through Sunday

Used For

Monitor therapeutic drug levels; evaluate for acetaminophen toxicity. Acetaminophen is as effective as aspirin when used for analgesia and antipyresis. It is used to treat headache, mild-to-moderate myalgia, arthralgia, chronic pain of cancer, postpartum pain, postoperative pain, and fever. The ceiling analgesic effect is obtained with a dose of 1 g.

Acetaminophen is the preferred alternative to aspirin for patients who cannot tolerate the latter, those with a coagulation disorder, or individuals with a history of peptic ulcer or reflux esophagitis. In children requiring only analgesia or antipyresis, acetaminophen may be preferred to aspirin because it is less toxic if an accidental overdose occurs. (Interestingly, acetaminophen overdosage in children younger than six years is rarely, if ever, associated with hepatotoxicity, but such protection is lost by adolescence.) Further, no epidemiological association has been demonstrated between acetaminophen and Reye syndrome in children or adolescents with influenza A or B or varicella (chickenpox).

Acetaminophen is unsatisfactory for conditions requiring potent anti-inflammatory activity (rheumatic disease, juvenile arthritis, dysmenorrhea, sunburn). Unlike aspirin, acetaminophen does not antagonize the effects of uricosuric agents and may be used in patients with gouty arthritis who are taking a uricosuric.