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Test Code ACBNAB Acetylcholine Binding Antibody, Serum

Performing Laboratory

Quest Nichols-Valencia

Methodology

Radioimmunoassay (RIA)

Reference Values

 

Negative ≤0.30 nmol/L
Equivocal 0.31-0.49 nmol/L
Positive ≥0.50 nmol/L

 

Test Classification and CPT Coding

83519

Day(s) and Time(s) Performed

Sat up Tuesday - Saturday

Physician Office Specimen Requirements

Container/Tube:  Gold-top tube(s)

Specimen:  1 mL of serum(0.5 mL min)

Transport Temperature:  Refrigerate

Computer Interface Code

PDM #  5901700

Useful For

Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.