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Test Code ACBLAB Acetylcholine Blocking Antibody, Serum

Performing Laboratory

Quest Diagnostics Nichols Inst San Juan Capistrano

Methodology

Radiobinding Assay

Reference Values

<32 % binding inhibition

Test Classification and CPT Coding

83519

Day(s) and Time(s) Performed

Sunday, Tuesday and  Thursday

Physician Office Specimen Requirements

Container/Tube:  Gold-top tube(s)

Specimen:  1 mL of serum (0.5 mL min)

Transport Temperature:  Refrigerate

Computer Interface Code

PDM # 5901710

Useful For

Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR modulating antibodies cross-link AChR molecules on cell surface, promoting internalization, and decreasing AChR surface density. The AChR binding and modulating antibody assays have similar sensitivities, but performing them together increases sensitivity of antibody detection by approximately 5%.